VTP-27999
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更新时间:2024-04-22 13:33:33
- 常用名VTP-27999英文名methyl N-[2-[(R)-(3-chlorophenyl)-[(3R)-1-[[(2S)-2-(methylamino)-3-[(3R)-oxan-3-yl]propyl]carbamoyl]piperidin-3-yl]methoxy]ethyl]carbamate
- CAS号942142-51-0分子量525.08100
- 密度1.178g/cm3沸点703.1ºC at 760 mmHg
- 分子式C26H41ClN4O5熔点N/A
- MSDS闪点379ºC
- 符号信号词
VTP-27999 名称
- 中文名N-[2-[(R)-(3-氯苯基)[(3R)-1-[[[(2S)-2-(甲基氨基)-3-[(3R)-四氢-2H-吡喃-3-基]丙基]氨基]羰基]-3-哌啶基]甲氧基]乙基]氨基甲酸甲酯
- 英文名methyl N-[2-[(R)-(3-chlorophenyl)-[(3R)-1-[[(2S)-2-(methylamino)-3-[(3R)-oxan-3-yl]propyl]carbamoyl]piperidin-3-yl]methoxy]ethyl]carbamate
- 中文别名N-[2-[(R)-(3-氯苯基)[(3R)-1-[[[(2S)-2-(甲氨基)-3-[(3R)-四氢-2H-吡喃-3-基]丙基]氨基]羰基]-3-哌啶基]甲氧基]乙基]-氨基甲酸甲酯 |
- 英文别名Methyl (2-{(R)-(3-Chlorophenyl)[(3r)-1-({(2s)-2-(Methylamino)-3-[(3r)-Tetrahydro-2h-Pyran-3-Yl]propyl}carbamoyl)piperidin-3-Yl]methoxy}ethyl)carbamate |Methyl (2-((R)-(3-chlorophenyl)((R)-1-(((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propyl)carbamoyl)piperidin-3-yl)methoxy)ethyl)carbamate |QC-4593 |VTP-27999 |
VTP-27999 生物活性
- 描述VTP-27999是烷基胺肾素抑制剂。
- 相关类别信号通路 >> 代谢酶/蛋白酶 >> 肾素 研究领域 >> 心血管疾病
- 参考文献[1]. Lanqi Jia et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751 [2]. New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082.
VTP-27999 物理化学性质
- 密度1.178g/cm3
- 沸点703.1ºC at 760 mmHg
- 分子式C26H41ClN4O5
- 分子量525.08100
- 闪点379ºC
- 精确质量524.27700
- PSA101.16000
- LogP4.69060
- 折射率1.537
VTP-27999 合成路线
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VTP-27999 上游产品
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