VTP-27999 2,2,2-三氟乙酸盐

V T P - 2 7 9 9 9 2 , 2 , 2 - sān fú yǐ suān yán

更新时间：2024-04-28 21:34:01

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VTP-27999 2,2,2-三氟乙酸盐名称

中文名

N-[2-[(R)-(3-氯苯基)[(3R)-1-[[[(2S)-2-(甲基氨基)-3-[(3R)-四氢-2H-吡喃-3-基]丙基]氨基]羰基]-3-哌啶基]甲氧基]乙基]氨基甲酸甲酯，2,2,2-三氟乙酸盐
英文名

methyl N-[2-[(3-chlorophenyl)-[(3R)-1-[[(2S)-2-(methylamino)-3-[(3R)-oxan-3-yl]propyl]carbamoyl]piperidin-3-yl]methoxy]ethyl]carbamate,2,2,2-trifluoroacetic acid
中文别名

N-[2-[(R)-(3-氯苯基)[(3R)-1-[[[(2S)-2-(甲基氨基)-3-[(3R)-四氢-2H-吡喃-3-基]丙基]氨基]羰基]-3-哌啶基]甲氧基]乙基]-2,2,2-三氟乙酸氨基甲酸甲酯 |
英文别名

methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate trifluoroacetate |CS-0312 |methyl {2-[((R)-(3-chlorophenyl){(3R)-1-[({(2S)-2-(methyl-amino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]-3-piperidinyl}methyl)oxy]ethyl}carbamate trifluoroacetate |VTP-27999 (2,2,2-trifluoroacetate) |

VTP-27999 2,2,2-三氟乙酸盐生物活性

描述

VTP-27999是烷基胺肾素抑制剂。
相关类别

信号通路 >> 代谢酶/蛋白酶 >> 肾素研究领域 >> 心血管疾病
参考文献

[1]. New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082. [2]. Lanqi Jia? et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751 [3]. Ishchenko A, et al. Structure-based design technology contour and its application to the design of Renin inhibitors.J Chem Inf Model. 2012 Aug 27;52(8):2089-97. Epub 2012 Jul 25.

VTP-27999 2,2,2-三氟乙酸盐物理化学性质