A-803467

5-(4-氯苯基)-N-(3,5-二甲氧基苯基)-2-呋喃甲酰胺

5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide

A 803467是Nav1.8钠离子通道阻断剂，IC50为8 nM，比对Nav1.2，1.3，1.5和1.7的抑制性高100倍。

信号通路 >> 跨膜转运 >> 钠通道 研究领域 >> 神经疾病

[1]. McGaraughty, et al. A selective NaV1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide)], attenuates spinal neuronal activity in neuropathic rats. Journal of Pharmacology and Experimental Therapeutics (2008), [2]. Jarvis MF, et al. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8520-5. [3]. Joshi SK, et al. Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models. http://www.ncbi.nlm.nih.gov/pubmed/19070548 [4]. Kort ME, et al. Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6812-5.

1.3±0.1 g/cm3

450.6±45.0 °C at 760 mmHg

128-130?C

C₁₉H₁₆ClNO₄

357.788

226.3±28.7 °C

357.076782

60.70000

4.93

white to tan

0.0±1.1 mmHg at 25°C

1.611

Store at +4°C

DMSO: >10mg/mL

GHS07

Warning

H302

Xn

R22

NONH for all modes of transport

2932190090

2932190090

2932190090 其他结构上有非稠合呋喃环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:20.0%

品名, 成分含量, 用途

2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%