7-木糖基-紫杉醇

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更新时间：2024-06-28 02:50:47

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常用名

7-木糖基-紫杉醇

英文名

(2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9-oxo-7-(β-D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate
CAS号

90332-66-4

分子量

986.021
密度

1.5±0.1 g/cm3

沸点

1062.3±65.0 °C at 760 mmHg
分子式

C₅₂H₅₉NO₁₈

熔点

N/A
MSDS

闪点

596.3±34.3 °C
符号

信号词

7-木糖基-紫杉醇名称

中文名

7-木糖基-紫杉醇
英文名

(2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9-oxo-7-(β-D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate
中文别名

7-木糖基紫杉醇 |
英文别名

Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13- tetramethyl-5-oxo-4-(β-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- |(2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9-oxo-7-(β-D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate |Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13- tetramethyl-5-oxo-4-(D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- |(2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9-oxo-7-(D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate |benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- |7-Xylosyltaxol |

7-木糖基-紫杉醇生物活性

描述

7-xylosyltaxol(Taxol-7-xyloside)是紫杉醇衍生物。
相关类别

信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白信号通路 >> 细胞骨架 >> 微管/微管蛋白天然产物 >> 萜类化合物和糖苷研究领域 >> 癌症
参考文献

[1]. Yu SS, Sun QW, Zhang XP, et al. Content and distribution of active components in cultivated and wild Taxus chinensis var. mairei plants. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23(10):2641-7. [2]. Chao Z, Tan M, Paudel MK, et al. Development of an indirect competitive enzyme-linked immunosorbent assay (icELISA) using highly specific monoclonal antibody against paclitaxel. J Nat Med. 2012 Sep 25. [3]. Park SJ, Wu CH, Gordon JD, et al. Taxol induces caspase-10-dependent apoptosis. J Biol Chem. 2004 Dec 3;279(49):51057-67. Epub 2004 Sep 27. [4]. Rao S, He L, Chakravarty S, et al. Characterization of the Taxol binding site on the microtubule. Identification of Arg(282) in beta-tubulin as the site of photoincorporation of a 7-benzophenone analogue of Taxol. J Biol Chem. 1999 Dec 31;274(53):37990-4. [5]. Paclitaxel

7-木糖基-紫杉醇物理化学性质

密度

1.5±0.1 g/cm3
沸点

1062.3±65.0 °C at 760 mmHg
分子式

C₅₂H₅₉NO₁₈
分子量

986.021
闪点

596.3±34.3 °C
精确质量

985.373230
LogP

7.81
蒸汽压

0.0±0.3 mmHg at 25°C
折射率

1.646

7-木糖基-紫杉醇合成路线

共页

7-木糖基-紫杉醇用途

7-xylosyltaxol(Taxol-7-xyloside)是紫杉醇衍生物。

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