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7-木糖基-紫杉醇

7 - mù táng jī - zǐ shān chún

更新时间:2024-02-14 21:42:27

  • 常用名
    7-木糖基-紫杉醇
    英文名
    (2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9-oxo-7-(β-D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate
  • CAS号
    90332-66-4
    分子量
    986.021
  • 密度
    1.5±0.1 g/cm3
    沸点
    1062.3±65.0 °C at 760 mmHg
  • 分子式
    C52H59NO18
    熔点
    N/A
  • MSDS
    闪点
    596.3±34.3 °C
  • 符号
    信号词
7-木糖基-紫杉醇 名称
  • 中文名
    7-木糖基-紫杉醇
  • 英文名
    (2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9-oxo-7-(β-D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate
  • 中文别名
    7-木糖基紫杉醇 |
  • 英文别名
    Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13- tetramethyl-5-oxo-4-(β-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- |(2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9-oxo-7-(β-D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate |Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13- tetramethyl-5-oxo-4-(D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- |(2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9-oxo-7-(D-xylopyranosyloxy)-5,20-epoxytax-11-en-2-yl benzoate |benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- |7-Xylosyltaxol |
7-木糖基-紫杉醇 生物活性
  • 描述
    7-xylosyltaxol(Taxol-7-xyloside)是紫杉醇衍生物。
  • 相关类别
    信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白 信号通路 >> 细胞骨架 >> 微管/微管蛋白 天然产物 >> 萜类化合物和糖苷 研究领域 >> 癌症
  • 参考文献
    [1]. Yu SS, Sun QW, Zhang XP, et al. Content and distribution of active components in cultivated and wild Taxus chinensis var. mairei plants. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23(10):2641-7. [2]. Chao Z, Tan M, Paudel MK, et al. Development of an indirect competitive enzyme-linked immunosorbent assay (icELISA) using highly specific monoclonal antibody against paclitaxel. J Nat Med. 2012 Sep 25. [3]. Park SJ, Wu CH, Gordon JD, et al. Taxol induces caspase-10-dependent apoptosis. J Biol Chem. 2004 Dec 3;279(49):51057-67. Epub 2004 Sep 27. [4]. Rao S, He L, Chakravarty S, et al. Characterization of the Taxol binding site on the microtubule. Identification of Arg(282) in beta-tubulin as the site of photoincorporation of a 7-benzophenone analogue of Taxol. J Biol Chem. 1999 Dec 31;274(53):37990-4. [5]. Paclitaxel
7-木糖基-紫杉醇 物理化学性质
  • 密度
    1.5±0.1 g/cm3
  • 沸点
    1062.3±65.0 °C at 760 mmHg
  • 分子式
    C52H59NO18
  • 分子量
    986.021
  • 闪点
    596.3±34.3 °C
  • 精确质量
    985.373230
  • LogP
    7.81
  • 蒸汽压
    0.0±0.3 mmHg at 25°C
  • 折射率
    1.646

7-木糖基-紫杉醇 合成路线

共页

7-木糖基-紫杉醇 用途

7-xylosyltaxol(Taxol-7-xyloside)是紫杉醇衍生物。

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