美托咪定

美托咪定

medetomidine

Medetomidine(Domtor)是α2肾上腺素受体激动剂，对α2和α1肾上腺素受体的Ki分别为1.08 nM和1750 nM。

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体 天然产物 >> 生物碱 研究领域 >> 神经疾病

[1]. Wenger S, Hoby S, Wyss F, Adami C, Wenker C. Anaesthesia with medetomidine, midazolam and ketamine in six gorillas after premedication with oral zuclopenthixol dihydrochloride. Vet Anaesth Analg. 2012 Aug 8. doi: 10.1111/j.1467-2995.2012.00761.x. [2]. Gerritsmann H, Stalder GL, Seilern-Moy K, Knauer F, Walzer C. Comparison of S(+)-ketamine and ketamine, with medetomidine, for field anaesthesia in the European brown hare (Lepus europaeus). Vet Anaesth Analg. 2012 Jul 13. doi: 10.1111/j.1467-2995.2012. [3]. Kallio A, Koulu M, Scheinin H, Viikari J, Scheinin M. Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man. Acta Endocrinol (Copenh). 1988 Sep;119(1):11-5. [4]. Virtanen R, Savola JM, Saano V, Nyman L. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol. 1988 May 20;150(1-2):9-14. [5]. Stenberg D, Salvén P, Miettinen MV. Sedative action of the alpha 2-agonist medetomidine in cats. J Vet Pharmacol Ther. 1987 Dec;10(4):319-23.

1.1±0.1 g/cm3

381.9±11.0 °C at 760 mmHg

151.5 - 152.5ºC

C₁₃H₁₆N₂

200.279

191.3±5.7 °C

200.131348

28.68000

3.10

0.0±0.8 mmHg at 25°C

1.570

2933290090

2933290090

2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%