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盐酸环胞苷
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更新时间：2024-04-17 07:37:17
- 常用名盐酸环胞苷英文名(+)-rolipram
- CAS号85416-73-5分子量275.343
- 密度1.2±0.1 g/cm3沸点472.7±45.0 °C at 760 mmHg
- 分子式C16H21NO3熔点133-136ºC
- MSDS闪点239.7±28.7 °C
- 符号信号词
盐酸环胞苷 名称
- 中文名(S)-4-[3-(环戊基氧基)-4-甲氧基苯基]-2-吡咯烷酮
- 英文名(+)-rolipram
- 中文别名盐酸环胞苷 |(4S)-4-[3-(环戊基氧基)-4-甲氧基苯基]-2-吡咯烷酮 |S-(+)-咯利普兰 |
- 英文别名(4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone |S2127_Selleck |(4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one |1oyn |S- (+)-Rolipram |2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, (R)- |S-(+)-Rolipram |(4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one |S-(+)-4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidinone |(S)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one |(-)-rolipram |1xn0 |(4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone |(+)-rolipram |(4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one |2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)- |2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4S)- |(S)-(+)-Rolipram |
盐酸环胞苷 生物活性
- 描述(S)-(+)-Rolipram是cAMP特异的PDE4抑制剂，有抗炎活性，活性小于其R型对映体。
- 相关类别信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE) 研究领域 >> 炎症/免疫
- 参考文献[1]. Griswold, D.E., et al., Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation, 1993. 17(3): p. 333-44. [2]. Zhu, J., E. Mix, and B. Winblad, The antidepressant and antiinflammatory effects of rolipram in the central nervous system. CNS Drug Rev, 2001. 7(4): p. 387-98. [3]. MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr [4]. Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169(7):1525-36.
盐酸环胞苷 物理化学性质
- 密度1.2±0.1 g/cm3
- 沸点472.7±45.0 °C at 760 mmHg
- 熔点133-136ºC
- 分子式C16H21NO3
- 分子量275.343
- 闪点239.7±28.7 °C
- 精确质量275.152130
- PSA47.56000
- LogP1.43
- 蒸汽压0.0±1.2 mmHg at 25°C
- 折射率1.552
- 储存条件Store at RT
盐酸环胞苷 安全
- 海关编码2933790090
盐酸环胞苷 合成路线
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盐酸环胞苷 上游产品
盐酸环胞苷上游产品 0
盐酸环胞苷 海关
- 海关编码2933790090
- 中文概述2933790090 其他内酰胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:9.0% 普通关税:20.0%
- 申报要素品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
- Summary2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%
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