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阿奇霉素 A

ā qí méi sù A

更新时间：2024-04-08 10:43:39

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常用名

阿奇霉素 A

英文名

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
CAS号

76801-85-9

分子量

734.958
密度

1.2±0.1 g/cm3

沸点

815.2±65.0 °C at 760 mmHg
分子式

C₃₇H₇₀N₂O₁₂

熔点

126-136ºC
MSDS

闪点

446.8±34.3 °C
符号

GHS07

信号词

Warning

阿奇霉素 A 名称

中文名

阿奇霉素 A
英文名

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
中文别名

9-去氧-9a-氮杂-同型红霉素A去甲阿奇霉素 |去甲阿奇霉素 |阿奇霉素杂质A |
英文别名

9-deokso-9a-aza-9a-homoeritromicin A |Desmethylazithromycin |1-oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)- |9a-N-desmethyl azithromycin |(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2, 6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside |DD-Azaerythromycin A |10-Dihydro-10-deoxo-11-azaerythromycin A |9-Deoxo-9a-aza-9a-homo Erythromycin A(Desmethyl Azithromycin) |(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside |9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin A |9a-aza-9-deoxo-9a-homoerythromycin A |9-deoxo-9a-aza-9a-homoerythromycin |Azaerythromycin A |UNII-4LSP9FJT5B |1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β -D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)- |9-deoxo-9a-aza-9a-homoerythromycin A |Azathramycin |

阿奇霉素 A 生物活性

描述

Azathramycin 是一种抗生素。
相关类别

信号通路 >> 自噬 >> 自噬信号通路 >> 抗感染 >> 细菌研究领域 >> 感染
参考文献

[1]. Noedl H, Krudsood S, Leowattana W, In vitro antimalarial activity of azithromycin, artesunate, and quinine in combination and correlation with clinical outcome. Antimicrob Agents Chemother. 2007 Feb;51(2):651-6. [2]. Hiwatashi Y, Maeda M, Fukushima H, Azithromycin suppresses proliferation, interleukin production and mitogen-activated protein kinases in human peripheral-blood mononuclear cells stimulated with bacterial superantigen. J Pharm Pharmacol. 2011 Oct;63(10):1320-6. [3]. Fernandez-Obregon AC. Azithromycin for the treatment of acne. Int J Dermatol. 2000 Jan;39(1):45-50.

阿奇霉素 A 物理化学性质