Argatroban是凝血酶选择性抑制剂。
阿加曲班
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更新时间:2024-04-09 10:57:17
- 常用名阿加曲班英文名Argatroban anhydrous
- CAS号74863-84-6分子量508.634
- 密度1.5±0.1 g/cm3沸点801.3±75.0 °C at 760 mmHg
- 分子式C23H36N6O5S熔点188-1890C
- MSDS闪点438.4±37.1 °C
- 符号信号词
阿加曲班 名称
- 中文名阿加曲班
- 英文名Argatroban anhydrous
- 中文别名(2R,4R)-4-甲基-1-[N-[(3-甲基-1,2,3,4-四氢-8-喹啉基)磺酰]-L-精氨酰]-2-哌啶甲酸 |(2R,4R)-1-[5-[(氨基亚氨基甲基)氨基]-1-氧代-2-[[(1,2,3,4-四氢-3-甲基-8-喹啉基)磺酰基]氨基]戊基]-4-甲基-2-哌啶羧酸 |阿各卓泮 |
- 英文别名Novastan |(2R,4R)-4-Methyl-1-{N-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]arginyl}-2-piperidinecarboxylic acid |Argatroban |(2R,4R)-4-Methyl-1-{N-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl]arginyl}piperidine-2-carboxylic acid |(2R,4R)-1-{N-(Diaminomethylene)-N-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-ornithyl}-4-methyl-2-piperidinecarboxylic acid |2-Piperidinecarboxylic acid, 1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-, (2R,4R)-, hydrate (1:1) |(2R,4R)-1-{N-(diaminomethylidene)-N-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl]-L-ornithyl}-4-methylpiperidine-2-carboxylic acid |(2R,4R)-4-Methyl-1-{N-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl]-L-arginyl}piperidine-2-carboxylic acid |(2R,4R)-1-(5-Carbamimidamido-2-{[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]amino}pentanoyl)-4-methyl-2-piperidinecarboxylic acid |MQPA |Argipidine |(2R,4R)-4-Methyl-1-[N2-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-2-piperidinecarboxylic Acid |Slonnon |[2R-[1(2S*),2a,4b]]-[partial]-1-[5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic Acid |2-Piperidinecarboxylic acid, 1-[5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-, (2R,4R)- |(2R,4R)-4-Methyl-1-{N-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl}-2-piperidinecarboxylic acid hydrate (1:1) |Argatroban monohydrate |MFCD00866789 |2-Piperidinecarboxylic acid, 1-[(2S)-5-[(diaminomethylene)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-, (2R,4R)- |Argatroban anhydrous |UNII:IY90U61Z3S |UNII:OCY3U280Y3 |(2R,4R)-4-Methyl-1-[(S)-N2-[[(R,S)-1,2,3,4-tetrahydro-3-methyl-8-quinolinyl]sulfonyl]arginyl]pipecolic Acid |
阿加曲班 生物活性
- 描述Argatroban是凝血酶选择性抑制剂。
- 相关类别信号通路 >> 代谢酶/蛋白酶 >> 凝血酶 天然产物 >> 生物碱 研究领域 >> 心血管疾病
- 参考文献[1]. Kawada, T., et al., Argatroban, an attractive anticoagulant, for left heart bypass with centrifugal pump for repair of traumatic aortic rupture. Jpn J Thorac Cardiovasc Surg, 1999. 47(3): p. 104-9. [2]. Jang, I.K., et al., A multicenter, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: myocardial infarction with novastan and TPA (MINT) study. J Am Coll Cardiol, 1999. 33(7): p. 1879-85.
阿加曲班 物理化学性质
- 密度1.5±0.1 g/cm3
- 沸点801.3±75.0 °C at 760 mmHg
- 熔点188-1890C
- 分子式C23H36N6O5S
- 分子量508.634
- 闪点438.4±37.1 °C
- 精确质量508.246796
- PSA186.09000
- LogP2.56
- 外观性状白色粉末
- 蒸汽压0.0±3.0 mmHg at 25°C
- 折射率1.674
- 储存条件Store at +4°C
- 分子结构
1、 摩尔折射率:129.78
2、 摩尔体积(cm3/mol):345.7
3、 等张比容(90.2K):968.8
4、 表面张力(dyne/cm):61.6
5、 极化率(10-24cm3):51.45
- 更多
1.性状:从乙醇结晶
2.熔点(ºC):188~191
阿加曲班 安全
- 危害码 (欧洲)Xn,N
- 风险声明 (欧洲)R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
- 安全声明 (欧洲)S28-S61-S28A
- 危险品运输编码UN 2020 6.1/PG 3
- WGK德国2
- RTECS号SK2450000
- 包装等级III
- 危险类别6.1
- 海关编码2935009090
阿加曲班 合成路线
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阿加曲班 上游产品
阿加曲班上游产品 0
阿加曲班 制备
- 0硝基-N-叔丁氧羰基精氨酸和4-甲基-2-吡啶羧酸乙酯反应,得到的化合物,再用3-甲基-8-喹啉磺酰氯酰化,得化合物,经水解成游离羧酸后,再在钯碳上催化氢化,得阿加曲班。
阿加曲班 海关
- 海关编码2935009090
- 中文概述2935009090 其他磺(酰)胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
- 申报要素品名, 成分含量, 用途
- Summary2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%
阿加曲班 用途