非西他滨

fēi xī tā bīn

更新时间：2024-04-26 07:14:01

前往商城一键下单

非西他滨名称

中文名

非西他滨
英文名

4-amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one
中文别名

4-氨基-1-[(2R,3S,4R,5R)-3-氟-4-羟基-5-(羟甲基)氧杂环戊-2-基]-5-碘嘧啶-2-酮 |4-氨基-1-(2-脱氧-2-氟-β-D-阿糖胞苷)-5-碘-2(1H)-嘧啶酮 |
英文别名

1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodocytosine |2'-Fluoro-5-iodo-1-b-D-arabinofuranosylcytosine |4-Amino-1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodo-2(1H)-pyrimidinone |FIAC |2'-Fluoro-5-iodo-aracytosine |2'-fluoro-5-iodoarabinosylcytosine |Fluorviodoaracytidine |DRG-0077 |4-Amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2(1H)-pyrimidinone |4-Amino-1-(2-deoxy-2-fluor-β-D-arabinofuranosyl)-5-iodpyrimidin-2(1H)-on |2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo- |4-Amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodopyrimidin-2(1H)-one |Fluoroiodoaracytidine |Fiacitabine |

非西他滨生物活性

描述

Fiacitabine(NSC 382097; FIAC; FOAC)是选择性HSV DNA复制抑制剂，对HSV1和HSV2的IC50分别为2.5 nM和12.6 nM。
相关类别

信号通路 >> 抗感染 >> HSV 研究领域 >> 感染
参考文献

[1]. Allaudeen HS, et al. Selective inhibition of DNA replication in herpes simplex virus infected cells by 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine. J Biol Chem. 1982 Oct 25;257(20):11879-82. [2]. Lopez C, et al. 2'-fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent. Antimicrob Agents Chemother. 1980 May;17(5):803-6.

非西他滨物理化学性质