8-异戊烯基柚皮素
8 - yì wù xī jī yòu pí sù
更新时间:2024-04-07 14:49:33
- 常用名8-异戊烯基柚皮素英文名8-Prenylnaringenin
- CAS号53846-50-7分子量340.370
- 密度1.3±0.1 g/cm3沸点597.6±50.0 °C at 760 mmHg
- 分子式C20H20O5熔点N/A
- MSDS闪点216.4±23.6 °C
- 符号信号词
8-异戊烯基柚皮素 名称
- 中文名8-异戊烯基柚皮素
- 英文名8-Prenylnaringenin
- 中文别名
- 英文别名8-Prenylnaringenin |5,7-Dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-2,3-dihydro-4H-chromen-4-one |4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-butenyl)- |
8-异戊烯基柚皮素 生物活性
- 描述8-prenylnaringenin 是一种从啤酒花穗 (Humulus lupulus) 中分离到的异戊烯类黄酮,具有细胞毒性。8-prenylnaringenin 能通过诱导内源性、外源性通路介导的凋亡,对 HCT-116 结肠癌细胞产生抗增殖活性。8-Prenylnaringenin 能通过激活小鼠 Akt 磷酸化途径,促进其从静止诱导的停用性肌肉萎缩中恢复。
- 相关类别信号通路 >> 细胞凋亡 >> 细胞凋亡 研究领域 >> 癌症
- 参考文献[1]. Koosha S, et al. Antiproliferative and apoptotic activities of 8-prenylnaringenin against human colon cancer cells. Life Sci. 2019 Jul 3:116633. [2]. Mukai R, et al. 8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice. Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1022-R1031. [3]. Stompor M, et al. In Vitro Effect of 8-Prenylnaringenin and Naringenin on Fibroblasts and Glioblastoma Cells-Cellular Accumulation and Cytotoxicity. Molecules. 2017 Jun 30;22(7).
8-异戊烯基柚皮素 物理化学性质
- 密度1.3±0.1 g/cm3
- 沸点597.6±50.0 °C at 760 mmHg
- 分子式C20H20O5
- 分子量340.370
- 闪点216.4±23.6 °C
- 精确质量340.131073
- PSA86.99000
- LogP5.28
- 蒸汽压0.0±1.8 mmHg at 25°C
- 折射率1.642
- 储存条件2-8°C
8-异戊烯基柚皮素 安全
- 危险品运输编码NONH for all modes of transport
8-异戊烯基柚皮素 合成路线
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