四氢小檗碱

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更新时间：2024-05-05 13:41:54

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四氢小檗碱名称

中文名

四氢小檗碱
英文名

canadine
中文别名

二氢小檗碱 |坎那定 |5,8,13,13A-四氢-9,10-二甲氧基-6H-苯并[G]苯并-1,3-二恶茂并[5,6-A]喹嗪 |
英文别名

l-Xanthopuccine |Hydroberberine |6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine, 5,8,13,13a-tetrahydro-9,10-dimethoxy- |9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline |9,10-Dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline |canadine |Tetrahydroberberine,THB |l-Canadine |(±)-Canadine |EINECS 208-338-2 |5,6,13,13a-Tetrahydro-9,10-dimethoxy-2,3-(methylenedioxy)-8H-dibenzo[a,g]quinolizine |MFCD00067284 |6H-1,3-Benzodioxolo[5,6-a]benzo[g]quinolizine, 5,8,13,13a-tetrahydro-9,10-dimethoxy- |dl-Canadine |UNII:V2SSH085X8 |l-Tetrahydroberberine |5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine |THB |Tetrahydroberberine |5,6,13,13a-Tetrahydro-9,10-dimethoxy-2,3-(methylenedioxy)-8H-dibenzo(a,g)quinolizine |dl-Tetrahydroberberine |9,10-bis(methyloxy)-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline |xanthopuccine |

四氢小檗碱生物活性

描述

四氢小檗碱(Tetrahydroberberine)是从延胡索中分离出来的一种异喹啉类生物碱，对D2和5-HT1A受体uM级亲和力。
相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体信号通路 >> 神经信号通路 >> 多巴胺受体天然产物 >> 生物碱研究领域 >> 神经疾病
参考文献

[1]. Lee TH, et al. Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function. J Pharmacol Exp Ther. 2011 Sep;338(3):917-24. [2]. Niwa M, et al. Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate. Pharmacology. 1991;43(6):329-36.

四氢小檗碱物理化学性质