CP-724714
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更新时间:2024-05-19 14:29:01
- 常用名CP-724714英文名E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide
- CAS号383432-38-0分子量469.535
- 密度1.3±0.1 g/cm3沸点687.3±55.0 °C at 760 mmHg
- 分子式C27H27N5O3熔点N/A
- MSDS闪点369.5±31.5 °C
- 符号信号词
CP-724714 名称
- 中文名2-甲氧基-N-[(2E)-3-[4-[[3-甲基-4-[(6-甲基-3-吡啶基)氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯-1-基]乙酰胺
- 英文名E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide
- 中文别名
- 英文别名Kumarin |2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide |Rattex |CUMARIN |COUMARINE |chromen-2-one |2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide |2-Methoxy-N-{(2E)-3-[4-({3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl}amino)-6-quinazolinyl]-2-propen-1-yl}acetamide |Acetamide, 2-methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]- |CP-724714 |
CP-724714 生物活性
- 描述CP-724,714是HER2/ErbB2抑制剂,IC50为10 nM,比对EGFR,InsR,IRG-1R,PDGFR,VEGFR2,Abl,Src和c-Met的抑制性高640倍。
- 相关类别研究领域 >> 癌症
- 靶点ErbB2:10 nM (IC50)
- 参考文献[1]. Jani JP, et al. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res, 2007, 67(20), 9887-9893. [2]. Feng B, et al. Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714. Toxicol Sci, 2009, 108(2), 492-500.
CP-724714 物理化学性质
- 密度1.3±0.1 g/cm3
- 沸点687.3±55.0 °C at 760 mmHg
- 分子式C27H27N5O3
- 分子量469.535
- 闪点369.5±31.5 °C
- 精确质量469.211395
- PSA98.26000
- LogP4.05
- 蒸汽压0.0±2.1 mmHg at 25°C
- 折射率1.663
CP-724714 合成路线
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CP-724714 上游产品
CP-724714上游产品 0