4,5,6,7-四氯茚满-1,3-二酮

4 , 5 , 6 , 7 - sì lǜ yìn mǎn - 1 , 3 - èr tóng

更新时间：2024-04-21 08:10:20

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4,5,6,7-四氯茚满-1,3-二酮名称

中文名

4,5,6,7-四氯茚满-1,3-二酮
英文名

4,5,6,7-tetrachloroindene-1,3-dione
中文别名
英文别名

1H-Indene-1,3(2H)-dione, 4,5,6,7-tetrachloro- |4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione |Ubiquitin C-Terminal Hydrolase L3 Inhibitor |Ubiquitin Thiolesterase L3 Inhibitor |4,5,6,7-Tetrachloroindan-1,3-dione |4,5,6,7-Tetrachlorindan-1,3-dion |4,5,6,7-Tetrachlorphenyl-1,3-indandion |4,5,6,7-tetrachloroindane-1,3-dione |UCH-L3 Inhibitor |TCID |Ubiquitin C-Terminal Esterase L3 Inhibitor |

4,5,6,7-四氯茚满-1,3-二酮生物活性

描述

TCID (4,5,6,7-Tetrachloroindan-1,3-dione) 是一种有效的选择性神经元泛素 C 末端水解酶 (UCH-L3) 抑制剂，IC50 为 0.6 μM。TCID 减少脑干和脊髓原代神经元中的甘氨酸转运蛋白 GlyT2 泛素化。
相关类别

研究领域 >> 心血管疾病信号通路 >> 细胞周期/DNA损伤 >> 去泛素化酶
靶点

IC50: 0.6 μM (UCH-L3) and 75 μM (UCH-L1)[1]
体外研究

TCID（4,5,6,7-四氯吲哚-1,3-二酮；化合物11）以75μM的IC50抑制UCH-L1[1]。TCID（10μM；1,2小时）减少脑干和脊髓原代神经元中甘氨酸转运体GlyT2的泛素化[2]。
参考文献

[1]. Liu Y, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cellline. Chem Biol. 2003 Sep;10(9):837-46. [2]. de Juan-Sanz J, et al. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS One. 2013;8(3):e58863.

4,5,6,7-四氯茚满-1,3-二酮物理化学性质

4,5,6,7-四氯茚满-1,3-二酮 msds

4,5,6,7-四氯茚满-1,3-二酮安全

4,5,6,7-四氯茚满-1,3-二酮合成路线

共页

4,5,6,7-四氯茚满-1,3-二酮海关

海关编码

2914700090
中文概述

2914700090 其他酮及醌的卤化、磺化衍生物（包括硝化和亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%
申报要素

品名, 成分含量, 用途, 丙酮报明包装
Summary

HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

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