Fluorogestone Acetate (also known as Flurogestone Acetate, Flugestone Acetate, Fluorogesterone Acetate) was first synthesised by G. D. Searle and Company in 1959. The chemical, which has progestogen activity, was identified as SC-9880. Fluorogestone acetate showed a high potency with short duration of activity and performed physiologically similar to progesterone. FGA was approximately 20 ?– 25 times more potent than progesterone. Flurogestone acetate was shown to be readily absorbed from impregnated sponges. A 30mg impregnated sponge was effective in blocking ovulation and oestrus, once the sponge was removed impregnated ewes showed visible oestrus, and if inseminated 2 to 4 days after sponge removal showed high conception rates. (Source: http://pharmplex.com.au/Technical/fluorogestone_acetate_sheep_goat.htm).
醋酸氟孕酮
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更新时间:2024-05-02 04:51:10
- 常用名醋酸氟孕酮英文名Flugestone 17-Acetate
- CAS号2529-45-5分子量406.488
- 密度1.2±0.1 g/cm3沸点526.7±50.0 °C at 760 mmHg
- 分子式C23H31FO5熔点267.5ºC
- MSDS闪点272.3±30.1 °C
- 符号信号词
- 中文名氟孕酮醋酸酯
- 英文名Flugestone 17-Acetate
- 中文别名醋酸氟孕酮 |
- 英文别名Flurogestone Acetate |[(8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate |EINECS 219-776-9 |9-Fluoro-11β,17-dihydroxypregn-4-ene-3,20-dione 17-acetate |9-Fluoro-11b,17-dihydroxyprogesterone 17-Acetate |Progesterone, 9-fluoro-11β,17-dihydroxy-, 17-acetate |Pregn-4-ene-3,20-dione, 17-(acetyloxy)-9-fluoro-11-hydroxy-, (11β)- |Pregn-4-ene-3,20-dione, 9-fluoro-11-β,17-dihydroxy-, 17-acetate |Flugestone acetate |UNII-X60881643X |Synchronate |(11β)-9-Fluoro-11-hydroxy-3,20-dioxopregn-4-en-17-yl acetate |17a-Acetoxy-9a-fluoro-11b-hydroxyprogesterone |9-Fluoro-11b,17-dihydroxypregn-4-ene-3,20-dione-17-acetate |MFCD00243094 |Cronolone |
- 密度1.2±0.1 g/cm3
- 沸点526.7±50.0 °C at 760 mmHg
- 熔点267.5ºC
- 分子式C23H31FO5
- 分子量406.488
- 闪点272.3±30.1 °C
- 精确质量406.215546
- PSA80.67000
- LogP1.93
- 蒸汽压0.0±3.1 mmHg at 25°C
- 折射率1.548
- 分子结构
1、 摩尔折射率:103.76
2、 摩尔体积(cm3/mol):326.6
3、 等张比容(90.2K):858.3
4、 表面张力(dyne/cm):47.6
5、 极化率(10-24cm3):41.13
- 计算化学
1.疏水参数计算参考值(XlogP):无
2.氢键供体数量:1
3.氢键受体数量:6
4.可旋转化学键数量:3
5.互变异构体数量:10
6.拓扑分子极性表面积80.7
7.重原子数量:29
8.表面电荷:0
9.复杂度:820
10.同位素原子数量:0
11.确定原子立构中心数量:7
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1
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