PD168393

N-[4-[(3-溴苯基)氨基]-6-喹唑啉]-2-丙酰胺

N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide

PD168393是一个强的，不可逆转的EGFR抑制剂，IC50是0.7 nM.

信号通路 >> 自噬 >> 自噬 研究领域 >> 癌症

EGFR:0.7 nM (IC50)

[1]. Fry DW et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12022-7. [2]. Sun X et al. The activation of EGFR promotes myocardial tumor necrosis factor-α production and cardiac failure in endotoxemia. Oncotarget. 2015 Nov 3;6(34):35478-95. [3]. Li G et al. Modulation of ErbB2 blockade in ErbB2-positive cancers: the role of ErbB2 Mutations and PHLDA1. PLoS One. 2014 Sep 19;9(9):e106349. [4]. White KJ et al. Irritant activation of epithelial cells is mediated via protease-dependent EGFR activation. J Invest Dermatol. 2011 Feb;131(2):435-42.

1.6±0.1 g/cm3

571.1±50.0 °C at 760 mmHg

279℃

C₁₇H₁₃BrN₄O

369.215

299.2±30.1 °C

368.027252

70.40000

3.72

0.0±1.6 mmHg at 25°C

1.744

-20°C

NONH for all modes of transport