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(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐
( 3 E ) - 3 - [ ( 2 , 4 - èr jiǎ yǎng jī běn jī ) yà jiǎ jī ] - 3 , 4 , 5 , 6 - sì qīng - 2 , 3 ' - lián pǐ dìng èr yán suān yán
更新时间：2024-04-15 23:26:50
![(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐](https://harlan-storage.oss-cn-hangzhou.aliyuncs.com/harlan/caspic/373/156223-05-1.png)
- 常用名(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐英文名3-(2,4-Dimethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl
- CAS号156223-05-1分子量381.30
- 密度1.1±0.1 g/cm3沸点485.6±45.0 °C at 760 mmHg
- 分子式C19H22Cl2N2O2熔点216-217℃ (decomposition)
- MSDS闪点247.5±28.7 °C
- 符号信号词
(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐 名称
- 中文名(1:2),(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3-联吡啶盐酸盐
- 英文名3-(2,4-Dimethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl
- 中文别名(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐 |
- 英文别名3-(2,4-Dimethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl |3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-5,6-dihydro-4H-pyridin-2-yl]pyridine dihydrochloride |3-(2,4-dimethoxybenzylidene)anabaseine |2,3'-Bipyridine, 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-, (3E)- |3-(2,4-Dimethoxybenzyl)-3,4,5,6-tetrahydro-2,3'-bipyridine |(3E)-3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine |3-(2,4)-DiMethoxybenzylidineanabaseine |GTS-21 |DMXB-A |GTS 21 2HCl |GTS-21 (dihydrochloride) |
(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐 生物活性
- 描述GTS-21二盐酸盐是一种选择性α7烟碱型乙酰胆碱受体 (α7nAChR) 激动剂。
- 相关类别信号通路 >> 跨膜转运 >> 胆碱受体 信号通路 >> 神经信号通路 >> 胆碱受体 研究领域 >> 炎症/免疫
- 参考文献[1]. Yue Y, et al. GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-κB signaling pathway through the α7 nicotinic acetylcholine receptor. Int Immunopharmacol. 2015 Dec;29(2):504-12. [2]. Nullens S, et al. EFFECT OF GTS-21, AN ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST, ON CLP-INDUCED INFLAMMATORY, GASTROINTESTINAL MOTILITY, AND COLONIC PERMEABILITY CHANGES IN MICE. Shock. 2016 Apr;45(4):450-9.
(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐 物理化学性质
- 密度1.1±0.1 g/cm3
- 沸点485.6±45.0 °C at 760 mmHg
- 熔点216-217℃ (decomposition)
- 分子式C19H22Cl2N2O2
- 分子量381.30
- 闪点247.5±28.7 °C
- PSA43.71000
- LogP2.64
- 外观性状powder,faint yellow to dark yellow
- 蒸汽压0.0±1.2 mmHg at 25°C
- 折射率1.580
- 储存条件2-8°C
- 水溶解性H2O: >5mg/mL
(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐 安全
- 危险品运输编码NONH for all modes of transport
- WGK德国3
- RTECS号DW1764860
- 海关编码2933399090
(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐 合成路线
共页
(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐 海关
- 海关编码2933399090
- 中文概述2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
- Summary2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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