曲贝替定

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更新时间：2024-04-30 03:40:28

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曲贝替定名称

中文名

他比特啶
英文名

trabectedin
中文别名

他比特定 |曲贝替定 |
英文别名

ecteinascidin-743 |(1R,1'R,2'R,3'R,11'S,12'S,14'R)-5',6,12'-Trihydroxy-6',7-dimethoxy-7',21',30'-trimethyl-27'-oxo-3,4-dihydro-2H-spiro[isoquinoline-1,26'-[17,19,28]trioxa[24]thia[13,30]diazaheptacyclo[12.9.6.1.0.0.0.0]triaconta[4,6,8,15,20,22]hexaen]-22'-yl acetate |ET-743 |Trabectedin |ecteinascidin 743 |(1'R,6R,6aR,7R,13S,14S,16R) |Ecteinascidine 743 |Ecteinascidin |ET743 |Yondelis(R) |UNII-ID0YZQ2TCP |5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-,[6R-(6a,6a3,73,133,143,16a,20R*)] |Yondelis |

曲贝替定生物活性

描述

Trabectedin (Ecteinascidin-743 or ET-743)是海洋来源的抗癌剂。
相关类别

信号通路 >> 细胞凋亡 >> 细胞凋亡天然产物 >> 生物碱研究领域 >> 癌症
参考文献

[1]. Takahashi N, et al. Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and paclitaxel in human breast cancer cell linesin vitro and in vivo. Cancer Res. 2002 Dec 1;62(23):6909-15. [2]. Atmaca H, et al. A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett. 2013 Jun 20;221(2):128-136. [3]. Germano G, et al. Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells. Cancer Res. 2010 Mar 15;70(6):2235-44. [4]. Sessa C, et al. Phase I clinical and pharmacokinetic study of trabectedin and cisplatin in solid tumours. Eur J Cancer. 2009 Aug;45(12):2116-22.

曲贝替定物理化学性质