(R)-普拉克索

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更新时间：2024-06-05 22:51:36

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(R)-普拉克索名称

中文名

R-普拉克索
英文名

(6R)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
中文别名

(R)-普拉克索二盐酸化物 |(R)-普拉克索 |普拉克索杂质E |
英文别名

Dexpramipexole |(6R)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole |(R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine |(6R)-4,5,6,7-tetrahydro-N6-propylbenzothiazole-2,6-diamine |(R)-Pramipexole Dihydrochloride |Pramipexole [USAN:INN] |(R)-(+)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole |(R)-Pramipexole |(R)-(+)-pramipexole |

(R)-普拉克索生物活性

描述

Dexpramipexole(KNS-760704)也叫R-(+)-Pramipexole，是神经保护剂，是弱的非麦角类多巴胺受体激动剂。
相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体信号通路 >> 神经信号通路 >> 多巴胺受体研究领域 >> 神经疾病
参考文献

[1]. Rudnicki SA, Berry JD, Ingersoll E, et al. Dexpramipexole effects on functional decline and survival in subjects with amyotrophic lateral sclerosis in a Phase II study: subgroup analysis of demographic and clinical characteristics. Amyotroph Lateral Scler [2]. Alavian KN, Dworetzky SI, Bonanni L, et al. Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Res. 2012 Mar 29;1446:1-11. [3]. Cudkowicz M, Bozik ME, Ingersoll EW, et al. The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis. Nat Med. 2011 Nov 20;17(12):1652-6. [4]. Bozik ME, Mather JL, Kramer WG, et al. Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects. J Clin Pharmacol. 2011 Aug;51(8):1177-85. [5]. Cheah BC, Kiernan MC. Dexpramipexole, the R(+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Dec;13(12):911-20.

(R)-普拉克索物理化学性质

(R)-普拉克索安全

(R)-普拉克索合成路线

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(R)-普拉克索上游产品

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(R)-普拉克索海关

海关编码

2934999090
中文概述

2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素

品名, 成分含量, 用途
Summary

2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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