苯甲酸阿格列汀
běn jiǎ suān ā gé liè tīng
更新时间:2024-04-13 05:19:03
- 常用名苯甲酸阿格列汀英文名alogliptin benzoate
- CAS号850649-62-6分子量461.513
- 密度N/A沸点671.2ºC at 760 mmHg
- 分子式C25H27N5O4熔点N/A
- MSDS闪点359.7ºC
- 符号信号词
苯甲酸阿格列汀 名称
- 中文名2-[[6-[(3R)-3-氨基-1-哌啶基]-3,4-二氢-3-甲基-2,4-二氧代-1(2H)-嘧啶基]甲基]苯甲腈苯甲酸盐
- 英文名alogliptin benzoate
- 中文别名苯甲酸阿格利汀 |苯甲酸阿格列汀 |阿格列汀苯甲酸盐 |苯甲酸盐阿格列汀 |
- 英文别名Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-, benzoate (1:1) |2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile,benzoic acid |SYR 322 |Vipidia (TN) |Alogliptin (Benzoate) |Alogliptin benzoate |2-({6-[(3R)-3-Amino-1-piperidinyl]-3-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl}methyl)benzonitrile benzoate (1:1) |2-({6-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile benzoate (1:1) |alogliptin monobenzoate |Nesina |2-[6-[3(R)-Aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-ylmethyl]benzonitrile benzoate |
苯甲酸阿格列汀 生物活性
- 描述Alogliptin benzoate(SYR 322)是高活性DPP-4抑制剂,IC50<10 nM,比对DPP-8和DPP-9的抑制性高10000倍。
- 相关类别信号通路 >> 代谢酶/蛋白酶 >> 二肽基肽酶 研究领域 >> 代谢疾病
- 参考文献[1]. Rendell M, et al. Alogliptin benzoate for the treatment of type 2 diabetes. Expert Opin Pharmacother. 2012 Mar;13(4):553-63. [2]. Radha Andukuri, et al. Alogliptin: a new addition to the class of DPP-4 inhibitors. Diabetes Metab Syndr Obes. 2009; 2: 117-126. [3]. Takeuchi K, et al. Pharmacological and clinical profile of alogliptin benzoate (NESINA?).Nihon Yakurigaku Zasshi. 2011 Jan;137(1):43-50. [4]. Moritoh Y, et al. Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice.Eur J Pharmacol. 2008 Jul 7;588(2-3):325-32.
苯甲酸阿格列汀 物理化学性质
- 沸点671.2ºC at 760 mmHg
- 分子式C25H27N5O4
- 分子量461.513
- 闪点359.7ºC
- 精确质量461.206299
- PSA134.35000
- LogP2.54458
苯甲酸阿格列汀 合成路线
共页