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醋酸氟孕酮

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  • 常用名
    醋酸氟孕酮
    英文名
    Flugestone 17-Acetate
  • CAS号
    2529-45-5
    分子量
    406.488
  • 密度
    1.2±0.1 g/cm3
    沸点
    526.7±50.0 °C at 760 mmHg
  • 分子式
    C23H31FO5
    熔点
    267.5ºC
  • MSDS
    闪点
    272.3±30.1 °C
  • 符号
    信号词

用途

Fluorogestone Acetate (also known as Flurogestone Acetate, Flugestone Acetate, Fluorogesterone Acetate) was first synthesised by G. D. Searle and Company in 1959. The chemical, which has progestogen activity, was identified as SC-9880. Fluorogestone acetate showed a high potency with short duration of activity and performed physiologically similar to progesterone. FGA was approximately 20 ?– 25 times more potent than progesterone. Flurogestone acetate was shown to be readily absorbed from impregnated sponges. A 30mg impregnated sponge was effective in blocking ovulation and oestrus, once the sponge was removed impregnated ewes showed visible oestrus, and if inseminated 2 to 4 days after sponge removal showed high conception rates. (Source: http://pharmplex.com.au/Technical/fluorogestone_acetate_sheep_goat.htm).

名称
  • 中文名
    氟孕酮醋酸酯
  • 英文名
    Flugestone 17-Acetate
  • 中文别名
    醋酸氟孕酮 |
  • 英文别名
    Flurogestone Acetate |[(8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate |EINECS 219-776-9 |9-Fluoro-11β,17-dihydroxypregn-4-ene-3,20-dione 17-acetate |9-Fluoro-11b,17-dihydroxyprogesterone 17-Acetate |Progesterone, 9-fluoro-11β,17-dihydroxy-, 17-acetate |Pregn-4-ene-3,20-dione, 17-(acetyloxy)-9-fluoro-11-hydroxy-, (11β)- |Pregn-4-ene-3,20-dione, 9-fluoro-11-β,17-dihydroxy-, 17-acetate |Flugestone acetate |UNII-X60881643X |Synchronate |(11β)-9-Fluoro-11-hydroxy-3,20-dioxopregn-4-en-17-yl acetate |17a-Acetoxy-9a-fluoro-11b-hydroxyprogesterone |9-Fluoro-11b,17-dihydroxypregn-4-ene-3,20-dione-17-acetate |MFCD00243094 |Cronolone |
物理化学性质
  • 密度
    1.2±0.1 g/cm3
  • 沸点
    526.7±50.0 °C at 760 mmHg
  • 熔点
    267.5ºC
  • 分子式
    C23H31FO5
  • 分子量
    406.488
  • 闪点
    272.3±30.1 °C
  • 精确质量
    406.215546
  • PSA
    80.67000
  • LogP
    1.93
  • 蒸汽压
    0.0±3.1 mmHg at 25°C
  • 折射率
    1.548
  • 分子结构

    1、 摩尔折射率:103.76

    2、 摩尔体积(cm3/mol):326.6

    3、 等张比容(90.2K):858.3

    4、 表面张力(dyne/cm):47.6

    5、 极化率(10-24cm3):41.13

  • 计算化学

    1.疏水参数计算参考值(XlogP):无

    2.氢键供体数量:1

    3.氢键受体数量:6

    4.可旋转化学键数量:3

    5.互变异构体数量:10

    6.拓扑分子极性表面积80.7

    7.重原子数量:29

    8.表面电荷:0

    9.复杂度:820

    10.同位素原子数量:0

    11.确定原子立构中心数量:7

    12.不确定原子立构中心数量:0

    13.确定化学键立构中心数量:0

    14.不确定化学键立构中心数量:0

    15.共价键单元数量:1

合成路线

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